SSRIs probably reduce premenstrual symptoms

SSRIs are likely effective in reducing symptoms of PMS and PMDD, whether taken continuously or during the luteal phase, with continuous use showing slightly better results. The treatment helps with psychological, physical and functional symptoms, although effect sizes are generally small to moderate. SSRIs can reduce premenstrual symptoms significantly, and although not providing a cure, they could potentially reduce severe symptoms enough to improve quality of life.

However, SSRIs are associated with adverse effects (eg, gastrointestinal complications, nausea, fatigue, sexual dysfunction), which can impact quality of life. Long-term use can lead to persistent issues in these areas. Despite this, SSRIs remain a valuable option for managing PMDD and potentially PMS, especially in cases with severe symptoms.