Using clinical judgement to diagnose dementia

Using clinical judgement to diagnose dementia

Vanessa Jordan
PEARLS No.
704
Clinical question

How accurate is the clinical judgement of GPs for diagnosing cognitive impairment and dementia in symptomatic people presenting to primary care?

Bottom line

In practice, GPs are unlikely to use clinical judgement as a single test, either to confirm or exclude mild to moderate dementia or cognitive impairment, but findings from this review indicate that clinical judgement is likely to be more specific than sensitive.

It would be necessary to use additional tests to confirm the diagnosis for either dementia or cognitive impairment, or to confirm the absence of these conditions, but clinical judgement may inform the choice of further testing.

Many people who a GP judges as having dementia will have the condition. People with false negative diagnoses are likely to have less severe disease, and some could be identified by more formal testing. Some false positives may require similar practical support to those with dementia, but some – for example, people with depression – may potentially experience delayed intervention for an alternative treatable pathology.

Caveat

The strength of evidence is restricted by limitations in the primary studies regarding participant flow, and by heterogeneity in the data. This may in part reflect the historic practical difficulties of investigating a disease in a low-prevalence setting: large numbers of patients require evaluation to identify people with disease; evaluating large numbers of people with a reference standard is resource intensive and arguably burdensome for people who are unlikely to have a cognitive disorder.

Partial verification may have led to over-optimistic estimates of diagnostic accuracy in some studies.

Context

In primary care, GPs unavoidably reach a clinical judgement about a patient as part of their encounter, so clinical judgement can be an important part of the diagnostic evaluation. When evaluating patients for dementia, many GPs report using their own judgement to evaluate cognition, using information that is immediately available at the point of care, to decide whether someone has or does not have dementia, rather than more formal tests.

Cochrane Systematic Review

Creavin ST, et al. Clinical judgement by primary care physicians for the diagnosis of all‐cause dementia or cognitive impairment in symptomatic people. Cochrane Database Syst Rev 2022;6:CD012558. This review contains 10 trials with a total of 6087 participants.