Selective serotonin reuptake inhibitors may help men with premature ejaculation, but with risk of adverse events

The review did not include any active com­parators and, therefore, is unable to address how these drugs compare with other management approaches, such as topical anaesthetics, tramadol or alpha-1 adrenoreceptor antagonists, which are rec­ommended as treatment alternatives.

A specific concern in the use of SSRIs for depression is the potential risk of promoting suicidal ideation, although this remains an issue of controversy. The reported adverse events and study withdrawals of the included studies did not provide a signal for this outcome, but the overall number of participants and the relatively short follow‐up of these studies limit the ability to identify infrequent outcomes that might be associated with long‐term use.