Proton pump inhibitors effective for functional dyspepsia

PPIs were effective at reducing overall symptoms of FD, independent of the dose and duration of treatment. Treatment lasted from 2 weeks to over 6 weeks. The studies included in the analysis were generally of high methodological quality and a funnel plot found no evidence of publication bias. There was no evidence of a difference between PPIs and placebo on quality of life. There was no difference in the number of reported side effects when comparing PPIs, H2RAs and prokinetics.