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Little evidence on effective pharmacotherapies for sleep disturbances in dementia
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Little evidence on effective pharmacotherapies for sleep disturbances in dementia
Compared with placebo, how effective are pharmacotherapies for sleep disturbances in dementia?
The evidence reviewed suggested melatonin was unlikely to be of benefit to patients with Alzheimer disease (AD) and moderate-to-severe dementia and sleep problems. There was some evidence that a low dose (50mg) of trazodone improved sleep in people with AD, although a larger trial would be needed to be able to draw a more definitive conclusion on the balance of risks and benefits. Until further evidence emerges, trazodone and other hypnotic drugs should be used with particular caution in patients with AD or other dementias, with careful assessment of the risks (of treatment and of no treatment), efficacy and adverse effects in individuals.
Because of a lack of primary evidence, the implications of this review for practice are limited. There were no randomised controlled trials of many drugs that are widely prescribed, including benzodiazepine and non-benzodiazepine hypnotics.
Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population.
McCleery J et al. Pharmacotherapies for sleep disturbances in dementia. Cochrane Reviews, 2016, Issue 11. Art. No.: CD009178.DOI: 10.1002/14651858.CD009178.pub3. This review contains 6 studies involving 326 participants.