Combination nicotine replacement therapy more effective than single-form for smoking cessation

Combination NRT (fast‐acting form plus patch) resulted in approximately 15% to 36% higher long‐term quit rates than a single form of NRT. Nicotine gum (4mg) resulted in approximately 12% to 83% higher quit rates than nicotine gum (2mg), although there was some evidence to suggest this might vary based on nicotine dependence. Forms of fast‐acting NRT, such as gum and lozenge, were as effective a cessation aid as nicotine patches. There was some evidence that using NRT before a quit day could result in higher quit rates than beginning NRT on a quit day. Studies lasted for at least 6 months. Evidence for the comparative safety and tolerability of different types of NRT use was of low and very low certainty.