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Pharmacogenomics is a promising field that helps tailor medications to genes. In this article, clinical pharmacist Katrina Azer reviews its impact on clinical practice and the challenges that need to be overcome to adopt it
Kia ora and welcome to New Zealand Doctor Rata Aotearoa
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1. National Institute of General Medical Sciences. Pharmacogenomics.
2. PharmGKB. www.pharmgkb.org
3. Swen JJ, van der Wouden CH, Manson LE, et al. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet 2023;401(10374):347–56.
4. Connelly D. Pharmacogenomic testing pilot to start in general practice from June 2023. The Pharmaceutical Journal, 18 May 2023.
5. Arnone D, Omar O, Arora T, et al. Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders: Systematic review and meta-analysis of randomised controlled trials. Neurosci Biobehav Rev 2023;144:104965.
6. Krebs K, Milani L. Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good. Hum Genomics 2019;13(1):39.
Respiratory physician Lutz Beckert considers chronic obstructive pulmonary disease management, including the prevention of COPD, the importance of smoking cessation and pulmonary rehabilitation, and the lifesaving potential of addressing treatable traits. He also discusses the logic of inhaler therapy, moving from single therapy to dual and triple therapy when indicated, as well as other aspects of management
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