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Thousands of Kiwis Set to Access Newly Funded Vaccine to Help Protect Against Debilitating Disease
Thousands of Kiwis Set to Access Newly Funded Vaccine to Help Protect Against Debilitating Disease
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Over 55,000 Kiwis aged 65 years, now have access to a funded vaccine which according to new research can help protect them for up to ten years against shingles, an intensely painful disease.[1][2][3]
Pharmac is assessing other groups for funding including Maori and Pacific people 60+.[4]
Shingles is a viral infection caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes chickenpox. Even those who appear healthy but are aged 50+ are at risk of developing shingles.
Almost all adults aged over 50 already have the virus that causes shingles in their body due to an initial chickenpox infection. Around a third of these will develop shingles in their lifetime when the virus reactivates.[5]
The disease is preventable however, and a new study has shown the recently funded Shingrix vaccine can protect those aged 50+ from the effects of shingles for up to 10 years.[6][7]
Most commonly, the shingles rash or blisters wrap around one side of the torso. Shingles can also be intensely painful, and the disease is associated with a range of complications which for some people can include vision loss, cardiovascular and stroke events, hearing loss, scarring and neurological problems. [8][9][10]
Along with ongoing pain and possible secondary infection, in rare cases shingles can be fatal for some patients. [11][12]
Patients can be impacted by long term pain - known as postherpetic neuralgia (PHN) when damaged nerve fibres send exaggerated messages of pain from skin to brain. Around a third of people with shingles may develop PHN, which can last for months or years. The condition is more likely to occur in older patients and can be associated with depression, anxiety and weight loss.[13][14]
Research has shown two thirds (66%) of Kiwis aged over 50, the demographic most at risk of the disease, say they have little-to-no knowledge of the shingles virus - which health experts have labelled ‘concerning’.[15]
Pharmac has now advised it will fund Shingrix for those aged 65 and is assessing other patient groups such as Maori and Pasifika aged 60+. [16]
Dr Jenny Visser, senior lecturer at Otago University, says “as we age our immune system starts to wear down allowing the potential for the virus to reactivate.”
“Shingles is an incredibly painful virus and can result in hospitalisation along with severe complications. For those who are immunocompromised or living with an underlying disease it can be fatal,” she says. [17][18][19]
“Shingles is extremely painful and itchy as the virus becomes active it travels along the nerves and shows up as a skin rash. It is usually concentrated in one area of the torso, but it can move to other parts of the body including the eye, which can result in a loss of sight,” she says. [20]
“Patients are often unable to have clothing or bed linen touch their skin and one of the most common side effects is postherpetic neuralgia which means the patient can suffer from chronic pain even after the rash and blisters have disappeared,” she says.
Dr Visser advises New Zealanders aged 50+ who have been exposed to chickenpox to consult their GP about how to prevent the development of shingles.
In a move set to improve access to the vaccine and a first for New Zealand, all people 50+ can receive the vaccine through private purchase in pharmacy.
Brett Marett, medical director at GSK says “one in three adults will develop shingles in their lifetime and says the company is proud to be at the forefront of developing vaccines.” [21]
“We are pleased that vaccination with Shingrix offers protection against shingles for up to 10 years, allowing New Zealanders and their health providers peace of mind when it comes to duration of protection,” he says.
The Shingrix vaccine is shown to be over 90% effective at preventing shingles in all age groups 50 plus in clinical trials. Shingrix offers sustained protection against shingles for up to 10 years post-vaccination, and continues to be monitored. [22][23]
[1] Strezova A et al. Long-term protection against herpes zoster (HZ) by the adjuvanted recombinant zoster vaccine (RZV): interim efficacy, immune and safety results at approximately 10 years after initial vaccination. Open Forum Infectious Diseases. 2022
[2] Immunisation Advisory Centre. Shingrix. Accessible here.
[3] Bricout H, Haugh M, Olatunde O, Prieto RG. Herpes zoster-associated mortality in Europe: a systematic review. BMC Public Health. 2015 May 5;15:466. doi: 10.1186/s12889-015-1753-y. PMID: 25940080; PMCID: PMC4435558. Accessible here.
[4] Pharmac. Decision to widen access to the meningococcal B vaccine and secure supply of the shingles vaccine. Accessible here.
[5] Centers for Disease Control and Prevention. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2008 May;57(RR-5):1-30.
[6] Strezova A et al. Long-term protection against herpes zoster (HZ) by the adjuvanted recombinant zoster vaccine (RZV): interim efficacy, immune and safety results at approximately 10 years after initial vaccination. Open Forum Infectious Diseases. 2022
[7] Immunisation Advisory Centre. Shingrix. Accessible here.
[8] Cohen KR, Salbu RL, Frank J, Israel I. Presentation and management of herpes zoster (shingles) in the geriatric population. P T. 2013;38(4):217-227. Accessible here.
[9] Catron T, Hern HG. Herpes zoster ophthalmicus. West J Emerg Med. 2008;9(3):174-176. Accessible here.
[10] Erskine N, Tran H, Levin L, et al. A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events. PLoS One. 2017;12(7):e0181565. Published 2017 Jul 27. doi:10.1371/journal.pone.0181565. Accessible here.
[11] Immunisation Advisory Centre. Shingrix. Accessible here.
[12] Bricout H, Haugh M, Olatunde O, Prieto RG. Herpes zoster-associated mortality in Europe: a systematic review. BMC Public Health. 2015 May 5;15:466. doi: 10.1186/s12889-015-1753-y. PMID: 25940080; PMCID: PMC4435558. Accessible here.
[13] Erskine N, Tran H, Levin L, et al. A systematic review and meta-analysis on herpes zoster and the risk of cardiac and cerebrovascular events. PLoS One. 2017;12(7):e0181565. Published 2017 Jul 27. doi:10.1371/journal.pone.0181565. Accessible here.
[14] Sansone RA, Sansone LA. Herpes zoster and postherpetic neuralgia: an examination of psychological antecedents. Innov Clin Neurosci. 2014;11(5-6):31-34. Accessible here.
[15] GSK Shingles Consumer Market Research October 2021.
[16] Pharmac Application Tracker. Available here.
[17] Bricout H, Haugh M, Olatunde O, Prieto RG. Herpes zoster-associated mortality in Europe: a systematic review. BMC Public Health. 2015;15:466. Published 2015 May 5. doi:10.1186/s12889-015-1753-y. Accessible here.
[18] Jiahui Qian, Anita Elizabeth Heywood, Surendra Karki, Emily Banks, Kristine Macartney, Lorraine Chantrill, Bette Liu, Risk of Herpes Zoster Prior to and Following Cancer Diagnosis and Treatment: A Population-Based Prospective Cohort Study, The Journal of Infectious Diseases, Volume 220, Issue 1, 1 July 2019, Pages 3–11.
[19] Immunisation Advisory Centre. Shingrix. Accessible here.
[20] Harpaz R et al. Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-5):1-30.
[21] Harpaz R et al. Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008;57(RR-5):1-30.
[22] GlaxoSmithKline New Zealand. SHINGRIX Medsafe Data Sheet. 2022.
[23] Strezova A et al. Long-term protection against herpes zoster (HZ) by the adjuvanted recombinant zoster vaccine (RZV): interim efficacy, immune and safety results at approximately 10 years after initial vaccination. Open Forum Infectious Diseases. 2022