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Pharmacist prescriber Linda Bryant discusses the prophylactic treatment options available to a young woman with recurrent urinary tract infections, including over-the-counter products, antibiotics, an antiseptic and more
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1. Gbinigie O. Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia in older adults compared with other antibiotics used to treat UTIs. BMJ Evid Based Med 2018;23(6):233–34.
2. Botros C, Lozo S, Iyer S, et al. Methenamine hippurate compared with trimethoprim for the prevention of recurrent urinary tract infections: a randomized clinical trial. Int Urogynecol J 2022;33(3):571–80.
3. Bakhit M, Krzyzaniak N, Hilder J, et al. Use of methenamine hippurate to prevent urinary tract infections in community adult women: a systematic review and meta-analysis. Br J Gen Pract 2021;71(708):e528–37.
4. Harding C, Mossop H, Homer T, et al. Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial. BMJ 2022;376:e068229.
5. Ferrante KL, Wasenda EJ, Jung CE, et al. Vaginal estrogen for the prevention of recurrent urinary tract infection in postmenopausal women: A randomized clinical trial. Female Pelvic Med Reconstr Surg 2021;27(2):112–17.
6. National Institute for Health and Care Excellence. Urinary tract infection (recurrent): antimicrobial prescribing. 31 October 2018. https://www.nice.org.uk/guidance/ng112
7. Nickel JC, Saz-Leal P, Doiron RC. Could sublingual vaccination be a viable option for the prevention of recurrent urinary tract infection in Canada? A systematic review of the current literature and plans for the future. Can Urol Assoc J 2020;14(8):281–87.
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