Low response to losartan and metformin may be an issue of genetics, not adherence

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Low response to losartan and metformin may be an issue of genetics, not adherence

17 June 2020

Vanessa Weenink

Wednesday 17 June 2020, 01:30 AM

Cilazapril/hydrochlorothiazide was recently discontinued, providing an opportunity for blood pressure review in many patients

PHARMACOTHERAPY

Pharmacogenomics is an area that continues to expand, especially for medicines that target specific metabolic pathways or are metabolised by
enzymes that have polymorphisms. This article explores how genetic variation can influence two common medicines

Leanne Te Karu and Linda Bryant

Key points Losartan may reduce serum urate levels slightly (by 3–10 per cent), but this is not currently predictable. Losartan is unsuitable a

Pharmacy

Genetics

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How to Treat

+How to treat

Heart failure

Pharmacist prescribers Linda Bryant and Leanne Te Karu discuss positive polypharmacy for heart failure. Current evidence shows the intensive implementation of four medications offers the greatest benefit to most patients with heart failure, with significant reductions in cardiovascular mortality, heart failure hospitalisations and all-cause mortality

Wednesday 29 January 2025, 12:45 AM