Low response to losartan and metformin may be an issue of genetics, not adherence

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Practice

Low response to losartan and metformin may be an issue of genetics, not adherence

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Vanessa Weenink

Patient, health professional, suprised
Cilazapril/hydrochlorothiazide was recently discontinued, providing an opportunity for blood pressure review in many patients

PHARMACOTHERAPY

Pharmacogenomics is an area that continues to expand, especially for medicines that target specific metabolic pathways or are metabolised by
enzymes that have polymorphisms. This article explores how genetic variation can influence two common medicines

Leanne Te Karu and Linda Bryant

Key points Losartan may reduce serum urate levels slightly (by 3–10 per cent), but this is not currently predictable. Losartan is unsuitable a