Pharmacist prescribers Linda Bryant and Leanne Te Karu discuss positive polypharmacy for heart failure. Current evidence shows the intensive implementation of four medications offers the greatest benefit to most patients with heart failure, with significant reductions in cardiovascular mortality, heart failure hospitalisations and all-cause mortality
Unwrapping the effects of diet and nutrients on premenstrual syndrome
Unwrapping the effects of diet and nutrients on premenstrual syndrome
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In this article, dietitian Clarice Hebblethwaite reviews the symptoms of premenstrual syndrome and how they might be affected by herbal supplements, diet, vitamins and minerals
1. O'Brien PM. Helping women with premenstrual syndrome. BMJ 1993;307(6917):1471–75.
2. Tesch BJ. Herbs commonly used by women: an evidence-based review. Am J Obstet Gynecol 2003;188(5 Suppl):S44–55.
3. Hashim MS, Obaideen AA, Jahrami HA, et al. Premenstrual syndrome is associated with dietary and lifestyle behaviors among university students: A cross-sectional study from Sharjah, UAE. Nutrients 2019;11(8):1939.
4. Milewicz A, Jedrzejuk D. Premenstrual syndrome: from etiology to treatment. Maturitas 2006;55(Suppl 1):S47–54.
5. Moline ML, Zendell SM. Evaluating and managing premenstrual syndrome. Medscape Womens Health 2000;5(2):1–16.
6. Bertone-Johnson ER, Hankinson SE, Forger NG, et al. Plasma 25-hydroxyvitamin D and risk of premenstrual syndrome in a prospective cohort study. BMC Womens Health 2014;14:56.
7. Heidari H, Amani R, Feizi A, et al. Vitamin D supplementation for premenstrual syndrome-related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial. Sci Rep 2019;9(1):14939.
8. Chocano-Bedoya PO, Manson JE, Hankinson SE, et al. Dietary B vitamin intake and incident premenstrual syndrome. Am J Clin Nutr 2011;93(5):1080–86.
9. Wyatt KM, Dimmock PW, Jones PW, et al. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 1999;318(7195):1375–81.
10. Kashanian M, Mazinani R, Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet 2007;96(1):43–44.
11. Parazzini F. Magnesium in the gynaecological practice: a literature review. Magnes Res 2017;30(1):1–7.
12. Walker AF, De Souza MC, Vickers MF, et al. Magnesium supplementation alleviates premenstrual symptoms of fluid retention. J Womens Health 1998;7(9):1157–65.
13. Chocano-Bedoya PO, Manson JE, Hankinson SE, et al. Intake of selected minerals and risk of premenstrual syndrome. Am J Epidemiol 2013;177(10):1118–27.
14. Siahbazi S, Behboudi-Gandevani S, Moghaddam-Banaem L, et al. Effect of zinc sulfate supplementation on premenstrual syndrome and health-related quality of life: Clinical randomized controlled trial. J Obstet Gynaecol Res 2017;43(5):887–94.
15. Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J 2004;10(4):328–36.