Specialist GP Nikki Vadgama provides some tips to make your next paediatric eczema consult easier. She includes a review of new guidelines, resources, websites and medications for paediatric eczema management
Managing menopausal symptoms? Educate on ‘bioidentical hormones’
Managing menopausal symptoms? Educate on ‘bioidentical hormones’
![Progesterone cream applied to the skin](/sites/default/files/styles/cropped_image_16_7_/public/2017-12/iStock-597242598.jpg?itok=TYGU3WH4)
Following the introduction to what GPs need to know about complementary hormone therapy in the previous issue, here we look at the place, if any, of "bioidentical hormones" in menopause management
1. Rossouw JE, Anderson GL, Prentice RL et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288(3):321–33.
2. Lee JR. Bioidentical hormones: Dr John R. Lee's Three Rules for BHRT. Available online
3. Langer RD. The evidence base for HRT: what can we believe? Climacteric 2017;20(2):91–96.
4. Stuenkel CA, Davis SR, Gompel A et al. Treatment of symptoms of the menopause: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2015;100(11):3975–4011.
5. Vashisht A, Wadsworth F, Carey A et al. Bleeding profiles and effects on the endometrium for women using a novel combination of transdermal oestradiol and natural progesterone cream as part of a continuous combined hormone replacement regime. Br J Obstet Gynaecol 2005;112(10):1402–6.
6. Stute P, Neulen J, Wildt L. The impact of micronized progesterone on the endometrium: a systematic review. Climacteric 2016;19(4):316–28.
7. Hunt PJ, Gurnell EM, Huppert FA et al. Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial. J Clin Endocrinol Metab 2000;85(12):4650–56.
8. Fedorkow DM. ACP Journal Club. Review: In peri- or postmenopausal women, DHEA does not improve symptoms and increases androgenic side effects. Ann Intern Med 2015;162(10):JC9.
9. Brown ES, Park J, Marx CE et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867–73.
10. Ogilvie CM, Levenberg R, Milsom SR. Bioidentical testosterone cream: a rare cause of postmenopausal virilisation. Aust N Z J Obstet Gynaecol 2009;49(1):116–17.
11. Delfs TM, Klein S, Fottrell P et al. 24-hour profiles of salivary progesterone. Fertil Steril 1994;62(5):960–66.
12. Lobo RA. Hormone-replacement therapy: current thinking. Nat Rev Endocrinol 2017;13(4):220–31.
13. Nelson HD, Vesco KK, Haney E et al. Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis. JAMA 2006;295(17):2057–71.
14. Loprinzi CL, Sloan J, Stearns V et al. Newer antidepressants and gabapentin for hot flashes: an individual patient pooled analysis. J Clin Oncol 2009;27(17):2831–37.
15. Santoro N, Braunstein GD, Butts CL et al. Compounded bioidentical hormones in endocrinology practice: An Endocrine Society scientific statement. J Clin Endocrinol Metab 2016;101(4):1318–43.
16. Shifren JL, Gass ML, Group NRfCCoMWW. The North American Menopause Society recommendations for clinical care of midlife women. Menopause 2014;21(10):1038–62.