Always consider effects on drug levels when removing interacting medicines

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PRACTICE

Always consider effects on drug levels when removing interacting medicines

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Guest writer

Oedema swollen
When Derek’s phenytoin was discontinued, diltiazem could accumulate, and lower-limb oedema was the result

PHARMACOTHERAPY

The complexity of drug–drug interactions is highlighted in this article about a retired man who presents with a new symptom of lower-leg oedema

Leanne Te Karu and Linda Bryant

Key points, Always consider the possibility of adverse or unwanted effects when medicines are discontinued. While less common than with dihydropyridine calcium