Pharmacist prescribers Linda Bryant and Leanne Te Karu discuss positive polypharmacy for heart failure. Current evidence shows the intensive implementation of four medications offers the greatest benefit to most patients with heart failure, with significant reductions in cardiovascular mortality, heart failure hospitalisations and all-cause mortality
Goodfellow Gems #60
Goodfellow Gems #60
Wednesday 19 July 2017, 12:15 PM
Clozapine. Malignant constipation can kill
Clozapine is used for treatment-resistant schizophrenia. Agranulocytosis and neutropenia are the usual concerns but there are more deaths from ileus/m
References
1. Clozapine ¬ Close Monitoring Required. Medsafe (2015) http://www.medsafe.govt.nz/profs/PUArticles/June2015/June2015Clozapine.htm
2. Safer prescribing of high-risk medicines: Clozapine BPAC (2014) http://www.bpac.org.nz/BPJ/2014/July/safer-prescribing.aspx