Specialist GP Nikki Vadgama provides some tips to make your next paediatric eczema consult easier. She includes a review of new guidelines, resources, websites and medications for paediatric eczema management
Wednesday 14 August 2024, 12:45 AM
Tryptase: An important tool in the assessment of severe allergic disease
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Tryptase: An important tool in the assessment of severe allergic disease
Wednesday 31 January 2024, 12:30 AM
The patient’s serum tryptase level was elevated immediately following a bee sting and remained elevated one week later [Image: Aaron Burden on Unsplash]
Measurement of mast cell tryptase is a vital yet underused tool in the assessment of severe allergic and mast cell disorders. This article summarises the causes of elevated serum tryptase, indications for testing and interpretation of results
Key points, Tryptase measurement is an important tool in the diagnosis of anaphylaxis and mast cell disorders.
Tryptase levels can help determine the severity o, Pract Green w Pale Yellow
References
1. Sala-Cunill A, Cardona V, Labrador-Horrillo M, et al. Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients. Int Arch Allergy Immunol 2013;160(2):192–99.
2. Chollet MB, Akin C. Hereditary alpha tryptasemia is not associated with specific clinical phenotypes. J Allergy Clin Immunol 2022;149(2):728–35.e2.
3. Lee AYS. Elevated serum tryptase in non-anaphylaxis cases: A concise review. Int Arch Allergy Immunol 2020;181(5):357–64.
4. Gulen T, Akin C, Bonadonna P, et al. Selecting the right criteria and proper classification to diagnose mast cell activation syndromes: A critical review. J Allergy Clin Immunol Pract 2021;9(11):3918–28.
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