Mean cell volume: Big is not better and should always be explained

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Mean cell volume: Big is not better and should always be explained

By Ian Morison
Mowing Field
Like using lawn fertiliser to make a healthy lawn grow more vigorously, a high circulating iron level enhances haemoglobin synthesis [Image: Rémi Müller on Unsplash]

The most common causes of macrocytosis are probably excess alcohol consumption and liver disease, but this article also considers the less well recognised causes, including reticulocytosis, myelodysplastic syndrome, myeloma and others

Key points, Macrocytosis almost always points to a clinically significant diagnosis, and investigations usually need to move on from the low-yield tests for vitam, Pract Green w Pale Yellow