Dark skin, blue nails – could minocycline be the cause?

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In print

Pharmacotherapy

Dark skin, blue nails – could minocycline be the cause?

By Penny Clark

Wednesday 9 October 2024, 12:30 AM

[Image: Supplied]

This article discusses a case of minocycline-induced facial hyperpigmentation with later nail involvement

Key points, Hyperpigmentation of the skin (and other structures) is a rare adverse effect of minocycline (and doxycycline). It is more common with prolonged cou, Pract Green w Pale Yellow

Medicines and Therapies

References

1. Martins AM, Marto JM, Johnson JL, Graber EM. A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea. Antibiotics (Basel) 2021;10(7):757.

2. Eisen D, Hakim MD. Minocycline-induced pigmentation. Incidence, prevention and management. Drug Saf 1998;18(6):431–40.

3. Shute L, Walkty A, Embil JM. Minocycline-induced cutaneous hyperpigmentation. CMAJ 2020;192(34):E981.

4. Ahmad Y, Boutros H, Hanna K. Out of the blue: A case of blue subungual discoloration associated with prolonged tetracycline use. Cureus 2020;12(4):e7810.

5. Varghese K, Dykstra J, Bisbee E. Minocycline-induced hyperpigmentation of nails. Cureus 2023;15(5):e38640.

6. Ricardo JW, Shah K, Minkis K, Lipner SR. Blue skin, nail, and scleral pigmentation associated with minocycline. Case Rep Dermatol 2022;14(2):239–42.

7. Adib F, Wong J, Loftu R. Blue nails: a case of minocycline-induced hyperpigmentation. World Allergy Organization Journal 2020;13(8):100255.

8. Dalby C. A man with blue-grey nails. Aust J Gen Pract 2021;50(3):148–50.

9. Sujaya SN, Ranganath VS, Girish BS, et al. Topical minocycline induced bluish black hyperpigmentation in acne vulgaris patient: The first case report of topical application. JDDT 2024;14(4):4–6.

10. Wang RF, Ko D, Friedman BJ, et al. Disorders of hyperpigmentation. Part I. Pathogenesis and clinical features of common pigmentary disorders. J Am Acad Dermatol 2023;88(2):271–88.

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Wednesday 9 October 2024, 12:45 AM